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The pharmaceutical intermediates often used in drugs for various diseases like erectile dysfunction, hypertension, osteoarthritis and rheumatoid arthritis, osteoporosis, diabetes etc. Some of the intermediates are also used in the manufacture of Biocides and in fragrance industry as perfume enhancer s, biocide like Bronopol is used in wide household products such as soaps and shampoos.Intermediaries like Methyl phenyl butane and Sulphonamido phenyl hydrazine hydrochloride is used in synthesis celecoxib. Methylthio Acetophenone is used in synthesis vioxx (rofecoxib) and other new drugs. These intermediaries are largely used for osteoarthritis and rheumatoid arthritis. For osteoporosis intermediates like acetyl pyridine and for diabetes Thiazolidine Dione is used. Erythromycin Oxime is a drug intermediate often used for Azithromycin, Roxithromycin, and Clarithromycin. N,N -Dibenzyl Ethylenediamine Diacetate is an ideal intermediate used in manufacturing of Benzathine penicillin. Ortho Chlorobenzylamine is used to manufacturing Ticlopidine. Tetrachloroethyl chloroformate is an intermediate used to protect reagent for alcohol. Diphenyl Prolinol is used for asymmetric reduction of ketones to chiral alcohol. A wide range of pharmaceutical intermediates is manufactured by host of manufacturers.
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